142276-31-1
142276-31-1
Chemical Structure
Cidofovir diphosphate
- CAS No.: 142276-31-1
- Formula:C8H16N3O12P3
- Molecular Weight:439.15
IUPAC Name: (S)-(((1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic diphosphoric anhydride
InChIKey: FBSIEHDOPYOBJD-LURJTMIESA-N
SMILES: O=P(O)(O)OP(OP(CO[C@H](CO)CN1C(N=C(C=C1)N)=O)(O)=O)(O)=O
Biological Activity: Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cidofovir diphosphate | Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively. | |||||||||||||||||||||
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Cidofovir diphosphate-13C3 | Cidofovir diphosphate-13C3 is the 13C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV). | |||||||||||||||||||||
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References
