142784-65-4
Chemical Structure
SM-11044
- CAS No.: 142784-65-4
- Formula:C22H28BrFN2O4
- Molecular Weight:483.37
InChIKey: VGHBGPUSJITFJL-JUDYQFGCSA-N
SMILES: O[C@H](C1=CC(O)=C(C=C1)O)[C@H](NCCCC2=CC=C(C=C2)F)C(N3CCCC3)=O.Br
Biological Activity: SM-11044 is a β-adrenoceptor agonist with Ki values of 18.1 μM (β1), 4.1 μM (β2) and 1.3 μM (β3), showing higher binding selectivity for the β3-adrenoceptor. SM-11044 stimulates cAMP accumulation in cells expressing this receptor. SM-11044 mediates ileal relaxation, tracheal relaxation, pulmonary parenchymal relaxation, increased right atrial heart rate and adipocyte lipolysis[1].
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SM-11044 | SM-11044 is a β-adrenoceptor agonist with Ki values of 18.1 μM (β1), 4.1 μM (β2) and 1.3 μM (β3), showing higher binding selectivity for the β3-adrenoceptor. SM-11044 stimulates cAMP accumulation in cells expressing this receptor. SM-11044 mediates ileal relaxation, tracheal relaxation, pulmonary parenchymal relaxation, increased right atrial heart rate and adipocyte lipolysis. | |||||||||||||||||||||
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Keywords
