SM-11044
SM-11044 is a β-adrenoceptor agonist with Ki values of 18.1 μM (β1), 4.1 μM (β2) and 1.3 μM (β3), showing higher binding selectivity for the β3-adrenoceptor. SM-11044 stimulates cAMP accumulation in cells expressing this receptor. SM-11044 mediates ileal relaxation, tracheal relaxation, pulmonary parenchymal relaxation, increased right atrial heart rate and adipocyte lipolysis.
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- CAS No.: 142784-65-4
- Formula: C22H28BrFN2O4
- Molecular Weight:483.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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β1 adrenoceptor 18.1 μM (Ki) |
β2 adrenoceptor 4.1 μM (Ki) |
β3 adrenoceptor 1.3 μM (Ki) |
SM-11044 (Serial dilutions; 1 h) binds to β1-, β2-, and β3-adrenoceptors expressed in CHO cells with highest affinity for β3-adrenoceptors (Ki = 1 μM), followed by β2-adrenoceptors (Ki = 4 μM), and lowest affinity for β1-adrenoceptors (Ki = 18 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 142784-65-4
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Molecular Weight 483.37
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Formula C22H28BrFN2O4
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SMILES
O[C@H](C1=CC(O)=C(C=C1)O)[C@H](NCCCC2=CC=C(C=C2)F)C(N3CCCC3)=O.Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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