142852-50-4
Chemical Structure
Zanapezil free base
Synonym(s): TAK-147 free base
- CAS No.: 142852-50-4
- Formula:C25H32N2O
- Molecular Weight:376.53
IUPAC Name: 3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-yl)propan-1-one
InChIKey: PMBLXLOXUGVTGB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2CCCCNC2=C1)CCC3CCN(CC4=CC=CC=C4)CC3
Biological Activity: Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zanapezil free base | 99.23% | Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD). | ||||||||||||||||||||
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Keywords
