14286-84-1
Chemical Structure
Benzcyclane fumarate
Synonym(s): Bencyclane fumarate; Benzcyclan fumarate
- CAS No.: 14286-84-1
- Formula:C23H35NO5
- Molecular Weight:405.53
IUPAC Name: 3-((1-benzylcycloheptyl)oxy)-N,N-dimethylpropan-1-amine fumarate
InChIKey: LSTKNZAMFRGXCG-WLHGVMLRSA-N
SMILES: CN(C)CCCOC1(CC2=CC=CC=C2)CCCCCC1.O=C(O)/C=C/C(O)=O
Biological Activity: Benzcyclane fumarate (Bencyclane fumarate; Benzcyclan fumarate) is a vasodilator with serotonin receptor antagonism. Benzcyclane fumarate exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane fumarate relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane fumarate exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane fumarate relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane fumarate increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane fumarate is applicable to studies related to cerebral vascular circulation[1].
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Benzcyclane fumarate | Benzcyclane fumarate (Bencyclane fumarate; Benzcyclan fumarate) is a vasodilator with serotonin receptor antagonism. Benzcyclane fumarate exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane fumarate relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane fumarate exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane fumarate relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane fumarate increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane fumarate is applicable to studies related to cerebral vascular circulation. | |||||||||||||||||||||
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Keywords
