1428935-60-7
1428935-60-7
Chemical Structure
Durvalumab
Synonym(s): MEDI 4736
- CAS No.: 1428935-60-7
- Formula:N/A
- Molecular Weight:(146.32 kDa)
SMILES: [Durvalumab]
Biological Activity: Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2].
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Durvalumab | 99.60% | Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively. | ||||||||||||||||||||
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Durvalumab (anti-PD-L1) | 99.0% | Durvalumab (anti-PD-L1)(MEDI 4736) is a human anti-PD-L1 protein monoclonal antibody. Durvalumab (anti-PD-L1) completely blocks PD-L1 binding to PD-1 and CD80, IC 50 are 0.1 and 0.04 nM respectively, has anti-tumor activity. | ||||||||||||||||||||
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References
- [1]. Stewart R, et al. Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody. Cancer Immunol Res. 2015 Sep;3(9):1052-62. [Content Brief]
- [2]. Faiena I, et al. Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. Drug Des Devel Ther. 2018 Jan 23;12:209-215. [Content Brief]
