1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Durvalumab

Durvalumab (Synonyms: MEDI 4736)

Cat. No.: HY-P9919 Purity: 99.50%
Handling Instructions

Durvalumab (MEDI 4736) is an humanized anti-PD-L1 monoclonal antibody. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively.

For research use only. We do not sell to patients.

Durvalumab Chemical Structure

Durvalumab Chemical Structure

CAS No. : 1428935-60-7

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Estimated Time of Arrival: December 31
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Description

Durvalumab (MEDI 4736) is an humanized anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2].

IC50 & Target

IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2]

In Vivo

Durvalumab inhibits tumor growth in mouse xenograft models of human melanoma (A375) and pancreatic (HPAC) tumour cell lines, via a T-cell-mediated mechanism. Durvalumab (5-0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5-0.1 mg/kg for NOD/SCID mice with A375 tumor; administration i.p.; twice per week; for 3 weeks) significantly inhibits the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody. Tumor growth inhibition of the HPAC cells reaches 74%, whereas inhibition of the A375 cells reaches 77%. When administered in the absence of T cells, Durvalumab has no effect on the growth of the A375 tumor xenograft[2].

Animal Model: NOD/SCID mice with HPAC tumor, following coimplantation of primary human T cells; NOD/SCID mice with A375 tumor, following coimplantation of primary human T cells[2]
Dosage: 5, 1, 0.1, and 0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5, 1, and 0.1 mg/kg for NOD/SCID mice with A375 tumor
Administration: Administration i.p.; twice per week; for 3 weeks
Result: Significantly inhibited the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody.
Clinical Trial
CAS No.

1428935-60-7

SMILES

[Durvalumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

Purity: 99.50%

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Durvalumab
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