145603-76-5
Chemical Structure
Nalanthalide
- CAS No.: 145603-76-5
- Formula:C30H44O5
- Molecular Weight:484.67
IUPAC Name: (1S,2S,4aR,5R,8aR)-5-((2-methoxy-5,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)-1,4a-dimethyl-6-methylene-1-(4-methylpent-3-en-1-yl)decahydronaphthalen-2-yl acetate
InChIKey: RVADBFKZGNOVDI-PELMAWFUSA-N
SMILES: O=C1C(C[C@@H]2C(CC[C@@]3([H])[C@@](CC/C=C(C)/C)(C)[C@@H](OC(C)=O)CC[C@]23C)=C)=C(OC)OC(C)=C1C
Biological Activity: Nalanthalide is a voltage-gated potassium channel Kv1.3 blocker (IC50=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation[1][2].
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Nalanthalide | Nalanthalide is a voltage-gated potassium channel Kv1.3 blocker (IC50=3.9 µM) and a potential immunosuppressant. Nalanthalide can be used for research on inflammatory immune diseases, such as neuroinflammation. | |||||||||||||||||||||
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- [1]. Singh SB, et al. Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3. Org Lett. 2001 Jan 25;3(2):247-50. [Content Brief]
- [2]. Michael A Goetz, et al. Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentations. Tetrahedron Lett. 2001Feb 12;42(7):1255-1257.
Keywords
