14605-22-2
14605-22-2
Chemical Structure
Tauroursodeoxycholate
Synonym(s): Tauroursodeoxycholic acid; TUDCA; UR 906
- CAS No.: 14605-22-2
- Formula:C26H45NO6S
- Molecular Weight:499.70
IUPAC Name: 2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid
InChIKey: BHTRKEVKTKCXOH-LBSADWJPSA-N
SMILES: C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Biological Activity: Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2][3].
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Tauroursodeoxycholate | 99.95% | Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | ||||||||||||||||||||
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Tauroursodeoxycholate (Standard) | ≥98% | Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | ||||||||||||||||||||
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Tauroursodeoxycholate-d5 | Tauroursodeoxycholate-d5 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | |||||||||||||||||||||
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Tauroursodeoxycholate-d4 | 99.70% | Tauroursodeoxycholate-d4 is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. The product specifications provided below refer solely to the active content of Tauroursodeoxycholate-d4. |
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Tauroursodeoxycholate-d4-1 | Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-165651STaurochenodeoxycholic acid-d4 -
Similarity Score 1.00
HY-N2027RTaurochenodeoxycholic acid (Standard) -
Similarity Score 0.98
HY-19696BRTauroursodeoxycholate dihydrate (Standard) -
Similarity Score 0.92
HY-19696ASTauroursodeoxycholate-d4 sodium -
Similarity Score 0.92
HY-N2027STaurochenodeoxycholic acid-d4 sodium -
Similarity Score 0.91
HY-19696ARTauroursodeoxycholate sodium (Standard) -
Similarity Score 0.91
HY-N1429RTaurochenodeoxycholic acid sodium (Standard) -
Similarity Score 0.87
HY-B1788S1Taurocholic acid-d4 -
Similarity Score 0.86
HY-114360Taurohyodeoxycholic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [Content Brief]
- [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. [Content Brief]
- [3]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345. [Content Brief]
