148714-92-5
148714-92-5
Chemical Structure
Org 33201
- CAS No.: 148714-92-5
- Formula:C21H29ClN2S
- Molecular Weight:376.99
IUPAC Name: 1-(((2S,3aR)-3a-ethyl-9-(ethylthio)-2,3,3a,4,5,6-hexahydro-1H-phenalen-2-yl)methyl)-1H-imidazole hydrochloride
InChIKey: CQCWQGXXUFLLAL-KTWHHOSASA-N
SMILES: C(C)[C@@]12C=3C(=C(SCC)C=CC3CCC1)C[C@@H](CN4C=CN=C4)C2.Cl
Biological Activity: Org 33201 is an orally active and selective Aromatase inhibitor with an IC50 of 2.2 nM. Org 33201 inhibits the activity of Aromatase by binding to its heme iron. Org 33201 can be used in the study of estrogen-dependent diseases (such as postmenopausal breast cancer)[1][2].
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Org 33201 | Org 33201 is an orally active and selective Aromatase inhibitor with an IC50 of 2.2 nM. Org 33201 inhibits the activity of Aromatase by binding to its heme iron. Org 33201 can be used in the study of estrogen-dependent diseases (such as postmenopausal breast cancer). | |||||||||||||||||||||
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References
- [1]. Kui Lin, et al. Treatment of breast cancer using combination therapies comprising an ATP competitive AKT inhibitor, a CDK4/6 inhibitor, and fulvestrant. WO2021030248A1. WIPO. 2021-02-18.
- [2]. Vanden Bossche HV, et al. Aromatase inhibitors--mechanisms for non-steroidal inhibitors. Breast cancer research and treatment. 1994;30(1):43-55.
