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Cat. No.: HY-187622

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Org 33201

Org 33201 is an orally active and selective Aromatase inhibitor with an IC₅₀ of 2.2 nM. Org 33201 inhibits the activity of Aromatase by binding to its heme iron. Org 33201 can be used in the study of estrogen-dependent diseases (such as postmenopausal breast cancer).

For research use only. We do not sell to patients.

CAS No.: 148714-92-5
Formula: C₂₁H₂₉ClN₂S
Molecular Weight:376.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Org 33201 Chemical Structure

CAS No.: 148714-92-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Aromatase

2.2 nM (IC₅₀)

All Cytochrome P450 Isoforms :

In Vitro

Org 33201 potently inhibits aromatase activity in human placental microsomes, with an IC₅₀ of 2.2 nM, and acts as a competitive inhibitor by binding to heme iron^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Org 33201 (0.5-1 mg/kg; p.o.; single dose) reduces plasma estradiol levels in a dose-dependent manner in beagle dogs treated with FSH (HY-NP197)/hCG (HY-107953)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148714-92-5
Molecular Weight 376.99
Formula C₂₁H₂₉ClN₂S
SMILES

C(C)[C@@]12C=3C(=C(SCC)C=CC3CCC1)C[C@@H](CN4C=CN=C4)C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kui Lin, et al. Treatment of breast cancer using combination therapies comprising an ATP competitive AKT inhibitor, a CDK4/6 inhibitor, and fulvestrant. WO2021030248A1. WIPO. 2021-02-18.

[2]. Vanden Bossche HV, et al. Aromatase inhibitors--mechanisms for non-steroidal inhibitors. Breast cancer research and treatment. 1994;30(1):43-55.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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