152121-46-5
Chemical Structure
SB 203580 sulfone
- CAS No.: 152121-46-5
- Formula:C21H16FN3O2S
- Molecular Weight:393.43
IUPAC Name: 4-(4-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-imidazol-5-yl)pyridine
InChIKey: XEOVWJYINDYNSM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)(C)=O
Biological Activity: SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SB 203580 sulfone | 99.25% | SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Gallagher TF, et al., Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. Bioorg Med Chem. 1997 Jan;5(1):49-64. [Content Brief]
- [2]. Timothy F, et al. 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis. Bioorganic & Medicinal Chemistry Letters, 1995, 1171-1176.
Keywords
