153-91-3
153-91-3
Chemical Structure
α-Methyl-DL-tryptophan
Synonym(s): α-Methyltryptophan
- CAS No.: 153-91-3
- Formula:C12H14N2O2
- Molecular Weight:218.26
IUPAC Name: 2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid
InChIKey: ZTTWHZHBPDYSQB-UHFFFAOYSA-N
SMILES: CC(CC1=CNC2=CC=CC=C12)(C(=O)O)N
Biological Activity: α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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α-Methyl-DL-tryptophan | 99.92% | α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight. | ||||||||||||||||||||
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D-Trp-Aib | D-Trp-Aib is a dipeptide and amyloid-β inhibitor with a Kd of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-β-sheet, amorphous amyloid β clusters from misfolded amyloid β monomers and toxic amyloid β oligomers, and reduces toxic amyloid β1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of α‑synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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L-(+)-Abrine | 99.91% | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. | ||||||||||||||||||||
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Hypaphorine (Standard) | ≥98% | Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1. | ||||||||||||||||||||
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L-Tryptophanamide hydrochloride | 99.95% | L-Tryptophanamide (H-Trp-NH2) hydrochloride is tryptophanamide hydrochloride, a primary UV standard. L-Tryptophanamide hydrochloride is a metabolite downregulated after fermentation of sea buckthorn juice by Lactobacillus plantarum or Lactiplantibacillus plantarum, and is positively correlated with bitterness and astringency in taste sensory evaluation. L-Tryptophanamide hydrochloride can be used for metabolite analysis and flavor research. | ||||||||||||||||||||
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N-Acetyl-L-tryptophan (Standard) | 99.99% | N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite. | ||||||||||||||||||||
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Ac-DL-Trp-OH (Standard) | ≥98% | Ac-DL-Trp-OH (Standard) is the analytical standard of Ac-DL-Trp-OH. This product is intended for research and analytical applications. Ac-DL-Trp-OH is an endogenous metabolite. | ||||||||||||||||||||
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6-Methyl-DL-tryptophan | 99.22% | 6-Methyl-DL-tryptophan is a kind of biochemical reagent. | ||||||||||||||||||||
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D,L-Tryptophanamide hydrochloride | 99.13% | D,L-Tryptophanamide hydrochloride is a biochemical assay reagent. | ||||||||||||||||||||
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N,N-Dimethyl-L-tryptophan hydrochloride | N,N-Dimethyl-L-tryptophan hydrochloride is a tryptamine. | |||||||||||||||||||||
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N-Methyl-DL-tryptophan | N-Methyl-DL-tryptophan (N-Methyltryptophan) is a DL-tryptophan (HY-W012480) derivative with activity to stabilize tryptophan against degradation during acid hydrolysis of protein fibres. | |||||||||||||||||||||
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References
- [1]. Karunakaran S, et al. SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem. 2011 Sep 9;286(36):31830-8. [Content Brief]
- [2]. Sathish Sivaprakasam, et al. α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice. Biochem J. 2021 Apr 16;478(7):1347-1358. [Content Brief]
