153-91-3
153-91-3
Chemical Structure
α-Methyl-DL-tryptophan
Synonym(s): α-Methyltryptophan
- CAS No.: 153-91-3
- Formula:C12H14N2O2
- Molecular Weight:218.26
IUPAC Name: 2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid
InChIKey: ZTTWHZHBPDYSQB-UHFFFAOYSA-N
SMILES: CC(CC1=CNC2=CC=CC=C12)(C(=O)O)N
Biological Activity: α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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α-Methyl-DL-tryptophan | 99.99% | α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight. | ||||||||||||||||||||
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References
- [1]. Karunakaran S, et al. SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem. 2011 Sep 9;286(36):31830-8. [Content Brief]
- [2]. Sathish Sivaprakasam, et al. α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice. Biochem J. 2021 Apr 16;478(7):1347-1358. [Content Brief]
Keywords
