1536470-98-0
1536470-98-0
Chemical Structure
SML-10-70-1
- CAS No.: 1536470-98-0
- Formula:C25H42ClN7O13P2
- Molecular Weight:746.04
InChIKey: LNAHOHGGBNNBAI-CUHBELQGSA-N
SMILES: O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OCCNC(CCl)=O)(N[C@@H](C)C(OCC(CCC)CCC)=O)=O)(O)=O)O3)=C2N=C(N)N1
Biological Activity: SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM[1].
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SML-10-70-1 | SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 μM. | |||||||||||||||||||||
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References
Keywords
