1553-34-0
Chemical Structure
Metixene hydrochloride
- CAS No.: 1553-34-0
- Formula:C20H24ClNS
- Molecular Weight:345.93
IUPAC Name: 3-((9H-thioxanthen-9-yl)methyl)-1-methylpiperidine hydrochloride
InChIKey: RSXZRFHNNTTWCB-UHFFFAOYSA-N
SMILES: CN1CC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)CCC1.[H]Cl
Biological Activity: Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian[1][2][3].
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Metixene hydrochloride | Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride can be used for the research of parkinsonian. | |||||||||||||||||||||
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- [1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4. [Content Brief]
- [2]. J. Hagenah, et al. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. , 106(3-4), 301–307. doi:10.1007/s007020050159
- [3]. S L Levin, et al. Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control. Int J Clin Pharmacol Res. 1986;6(5):429-39. [Content Brief]
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