1561902-79-1
Chemical Structure
ICSN3250 hydrochloride
- CAS No.: 1561902-79-1
- Formula:C31H41ClN4O8
- Molecular Weight:633.13
IUPAC Name: 5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol) hydrochloride
InChIKey: VTTAAXQGVVGOFT-UHFFFAOYSA-N
SMILES: OC1=CC(C2=CN(C=C2C3=CC([N+]([O-])=O)=C(O)C(O)=C3)CCCN4CCCCCCCCCCCC4)=CC([N+]([O-])=O)=C1O.Cl
Biological Activity: ICSN3250 hydrochloride is a halitulin analogue and a mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer [1].
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ICSN3250 hydrochloride | ICSN3250 hydrochloride is a halitulin analogue and a mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer . | |||||||||||||||||||||
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Keywords
