1567915-38-1
Chemical Structure
MTI-31
Synonym(s): LXI-15029
- CAS No.: 1567915-38-1
- Formula:C26H30N6O3
- Molecular Weight:474.55
IUPAC Name: 3-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-2-((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide
InChIKey: LVPBYQVQBZLDAU-DZIBYMRMSA-N
SMILES: C[C@@H]1N(CCOC1)C2=NC3=C(C=CC(C4=CC(C(NC)=O)=CC=C4)=N3)C(N5C6CCC5COC6)=N2
Biological Activity: MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP. MTI-31 can be used for the research of breast cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MTI-31 | 99.92% | MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP. MTI-31 can be used for the research of breast cancer. | ||||||||||||||||||||
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Keywords
