1571957-95-3
Chemical Structure
p,p'-DDD-13C12
Synonym(s): 4,4'-DDD-13C12; p,p'-Dichlorodiphenyl dichloroethane-13C12
- CAS No.: 1571957-95-3
- Formula:C213C12H10Cl4
- Molecular Weight:331.95
IUPAC Name: 4,4'-(2,2-dichloroethane-1,1-diyl)bis(chlorobenzene-1,2,3,4,5,6-13C6)
InChIKey: AHJKRLASYNVKDZ-WCGVKTIYSA-N
SMILES: ClC(C([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)Cl)[13C]2=[13CH][13CH]=[13C]([13CH]=[13CH]2)Cl)Cl
Biological Activity: p,p'-DDD-13C12 is 13C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT[1][2][3].
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p,p'-DDD-13C12 | p,p'-DDD-13C12 is 13C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT. | |||||||||||||||||||||
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p,p'-DDD (Standard) | ≥98% | p,p'-DDD (Standard) is the analytical standard of p,p'-DDD (HY-B1984) . This product is intended for research and analytical applications. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats. | ||||||||||||||||||||
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p,p'-DDD-d8 | p,p'-DDD-d8 is the deuterium labeled p,p'-DDD. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats. | |||||||||||||||||||||
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p,p'-DDD | 99.37% | p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Mendel JL, et al. Conversion of p,p' -DDT to p,p' -DDD by intestinal flora of the rat. Science. 1966;151(3717):1527-1528. [Content Brief]
- [3]. Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro. Chemosphere. 2012;87(11):1288-1294. [Content Brief]
