159776-67-7
159776-67-7
Chemical Structure
Rizatriptan hemisulfate hemihydrate
Synonym(s): MK 462 hemisulfate hemihydrate
- CAS No.: 159776-67-7
- Formula:C15H19N5.1/2H2O4S.1/2H2O
- Molecular Weight:327.39
InChIKey: FATZVIFXWDKMCZ-UHFFFAOYSA-N
SMILES: O=S(O)(O)=O.CN(C)CCC1=CNC2=C1C=C(C=C2)CN3N=CN=C3.O.[1/2].[1/2]
Biological Activity: Rizatriptan (MK 462) hemisulfate hemihydrate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan hemisulfate hemihydrate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[1][2].
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Rizatriptan hemisulfate hemihydrate | Rizatriptan (MK 462) hemisulfate hemihydrate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan hemisulfate hemihydrate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system. | |||||||||||||||||||||
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References
- [1]. Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43(1):49-54. [Content Brief]
- [2]. Cumberbatch MJ, et al. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997 Jun 5;328(1):37-40. [Content Brief]
Keywords
