1616592-31-4
1616592-31-4
Chemical Structure
PhAc-ALGP-Dox
- CAS. Nr.: 1616592-31-4
- Formula:C45H58N5O19P
- Molecular Weight:1003.94
InChIKey: PHHKEDVCEAVUHV-RDDAFIBISA-N
SMILES: OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC([C@H]6N(CCC6)C(CNC([C@H](CC(C)C)NC([C@H](C)NC(CP(O)(O)=O)=O)=O)=O)=O)=O
Biological Activity:
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells[1].
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PhAc-ALGP-Dox | PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells. |
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