PhAc-ALGP-Dox
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells.
For research use only. We do not sell to patients.
- CAS No.: 1616592-31-4
- Formula: C45H58N5O19P
- Molecular Weight:1003.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PhAc-ALGP-Dox is sequentially activated via a tumor-specific two-step cleavage, initiated by extracellular THOP1 and further processed by FAPα/DPP4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1616592-31-4
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Molecular Weight 1003.94
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Formula C45H58N5O19P
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Sequence
{Phosphonoacetyl}-Ala-Leu-Gly-Pro-{Dox}
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Sequence Shortening
{Phosphonoacetyl}-ALGP-{Dox}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PhAc-ALGP-Dox Related Classifications
HY-P10760 Related Classifications
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