161877-70-9
Chemical Structure
Dabcyl-YVADAPV-EDANS
- CAS No.: 161877-70-9
- Formula:C61H76N12O14S
- Molecular Weight:1233.39
IUPAC Name: (3S,6S,9S,12S)-1-(4-((E)-(4-(dimethylamino)phenyl)diazenyl)phenyl)-3-(4-hydroxybenzyl)-6-isopropyl-9-methyl-12-(((S)-1-((S)-2-(((S)-3-methyl-1-oxo-1-((2-((5-sulfonaphthalen-1-yl)amino)ethyl)amino)butan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazatetradecan-14-oic acid
InChIKey: VOOSFUAACNZZDI-NCIMJASNSA-N
SMILES: O=S(O)(C1=CC=CC2=C1C=CC=C2NCCNC([C@H](C(C)C)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C4=CC=C(C=C4)/N=N/C5=CC=C(C=C5)N(C)C)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K+ deprivation-induced apoptosis of cerebellar granule neurons[1].
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Dabcyl-YVADAPV-EDANS | Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K+ deprivation-induced apoptosis of cerebellar granule neurons. | |||||||||||||||||||||
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