1639898-35-3
1639898-35-3
Chemical Structure
mGluR2 modulator 5
- CAS No.: 1639898-35-3
- Formula:C20H17F3N4O
- Molecular Weight:386.37
InChIKey: GOYOLHWWQMGLGG-ZDUSSCGKSA-N
SMILES: CC1=NC=CC(C2=C(C(N(C3=CC=C(C(F)(F)F)C=C3)C[C@@H]4C)=O)N4N=C2)=C1
Biological Activity: mGluR2 modulator 5 (Compound 11) is an orally active, selective mGluR2 negative allosteric modulator with an IC50 of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases[1].
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mGluR2 modulator 5 | mGluR2 modulator 5 (Compound 11) is an orally active, selective mGluR2 negative allosteric modulator with an IC50 of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases. | |||||||||||||||||||||
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References
Keywords
