165307-47-1
165307-47-1
Chemical Structure
CB-184
- CAS No.: 165307-47-1
- Formula:C22H21Cl2NO2
- Molecular Weight:402.31
IUPAC Name: (1R,5R,E)-8-(3,4-dichlorobenzylidene)-5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-7-one
InChIKey: SSPWSCFMVXPMNL-COSXAGSESA-N
SMILES: OC1=CC=CC([C@@]2(CCN3C)CC(/C([C@H]3C2)=C/C4=CC(Cl)=C(Cl)C=C4)=O)=C1
Biological Activity: CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CB-184 | CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18(7):938-49. [Content Brief]
- [2]. Keith W Crawford, et al. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443(1-3):207-9. [Content Brief]
Keywords
