CB-184
CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 165307-47-1
- Formula: C22H21Cl2NO2
- Molecular Weight:402.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Sigma Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 165307-47-1
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Molecular Weight 402.31
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Formula C22H21Cl2NO2
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SMILES
OC1=CC=CC([C@@]2(CCN3C)CC(/C([C@H]3C2)=C/C4=CC(Cl)=C(Cl)C=C4)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18(7):938-49. [Content Brief]
[2]. Keith W Crawford, et al. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443(1-3):207-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB-184 Related Classifications
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