17182-52-4
17182-52-4
Chemical Structure
8-Geranyloxy-5-methoxypsoralen
- CAS No.: 17182-52-4
- Formula:C22H24O5
- Molecular Weight:368.42
InChIKey: CTPXXQMJFXTTQZ-XNTDXEJSSA-N
SMILES: C/C(C)=C/CC/C(C)=C/COC1=C(OC=C2)C2=C(OC)C(C=C3)=C1OC3=O
Biological Activity: 8-geranyloxy-5-methoxypsoralen is a BACE1 inhibitor with an IC50 of 11.1 μM. 8-geranyloxy-5-methoxypsoralen potently inhibits BACE1 activity. 8-Geranyloxy-5-methoxypsoralen can be used for the research of Alzheimer's disease[1][2].
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8-Geranyloxy-5-methoxypsoralen | 8-geranyloxy-5-methoxypsoralen is a BACE1 inhibitor with an IC50 of 11.1 μM. 8-geranyloxy-5-methoxypsoralen potently inhibits BACE1 activity. 8-Geranyloxy-5-methoxypsoralen can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Marumoto S, et al. Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor. Bioorg Med Chem. 2012;20(2):784-788. [Content Brief]
- [2]. Murata K. Chemical diversity of β-secretase inhibitors from natural resources[J]. Natural Product Communications, 2019, 14(12): 1934578X19894819.
Keywords
