173584-44-6
Chemical Structure
Indoxacarb
Synonym(s): (S)-DPX-JW062
- CAS No.: 173584-44-6
- Formula:C22H17ClF3N3O7
- Molecular Weight:527.83
IUPAC Name: methyl (S)-7-chloro-2-((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)carbamoyl)-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
InChIKey: VBCVPMMZEGZULK-NRFANRHFSA-N
SMILES: COC([C@@]12C(C3=CC=C(Cl)C=C3C1)=NN(CO2)C(N(C4=CC=C(C=C4)OC(F)(F)F)C(OC)=O)=O)=O
Biological Activity: Indoxacarb ((S)-DPX-JW062) is an orally active Insecticide, Voltage-dependent sodium channel blocker, and Nicotinic acetylcholine receptor modulator. Indoxacarb induces HSP70, modulates hepatic IGF-I/IGF-II, induces oxidative stress/ROS, inhibits oxidative phosphorylation, and triggers Autophagy/Apoptosis. Indoxacarb impairs neurological function and impedes nerve excitation. Indoxacarb has been widely used for the control of agricultural and forestry pests, showing significant control efficacy against Homoptera, Coleoptera, and especially Lepidoptera insects[1][2][3].
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Indoxacarb | 98.08% | Indoxacarb ((S)-DPX-JW062) is an orally active Insecticide, Voltage-dependent sodium channel blocker, and Nicotinic acetylcholine receptor modulator. Indoxacarb induces HSP70, modulates hepatic IGF-I/IGF-II, induces oxidative stress/ROS, inhibits oxidative phosphorylation, and triggers Autophagy/Apoptosis. Indoxacarb impairs neurological function and impedes nerve excitation. Indoxacarb has been widely used for the control of agricultural and forestry pests, showing significant control efficacy against Homoptera, Coleoptera, and especially Lepidoptera insects. | ||||||||||||||||||||
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References
- [1]. Sandeep K, et al. Indoxacarb interaction alters immunotoxic and genotoxic potential of endotoxin. Journal of pesticide science. 2016 Aug 20;41(3):65-70.
- [2]. Ghelichpour M, et al. Expression of immune, antioxidant and stress related genes in different organs of common carp exposed to indoxacarb. Aquatic toxicology (Amsterdam, Netherlands). 2019 Mar;208:208-216.
- [3]. Wang W, et al. Indoxacarb triggers autophagy and apoptosis through ROS accumulation mediated by oxidative phosphorylation in the midgut of Bombyx mori. Pesticide biochemistry and physiology. 2024 Mar;200:105812.
