175522-42-6
Chemical Structure
Okadaic acid ammonium salt
- CAS No.: 175522-42-6
- Formula:C44H71NO13
- Molecular Weight:822.03
IUPAC Name: ammonium (R)-2-hydroxy-3-((2S,5R,6R,8S)-5-hydroxy-8-((R,E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-((1S,3S)-1-hydroxy-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-en-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-2-methylpropanoate
InChIKey: ZBOMSHVRJSJGNR-GHIYGBLASA-N
SMILES: O[C@H](CC1)[C@@](O[C@@H]1C[C@@](C)(O)C([O-])=O)(C=C2C)O[C@](C2)([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H](C5=C)O)([H])[C@@](O[C@]5([H])[C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])CC4)CC3.[NH4+]
Biological Activity: Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Okadaic acid ammonium salt | 99% | Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation. | ||||||||||||||||||||
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