179939-69-6
179939-69-6
Chemical Structure
SPA107
Synonym(s): Hemiasterlin methyl ester
- CAS No.: 179939-69-6
- Formula:C31H48N4O4
- Molecular Weight:540.74
InChIKey: SLQRJGFANAFMIA-ZQBASNNKSA-N
SMILES: COC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
Biological Activity: SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC50 of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC50 of 0.5 nM[1].
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SPA107 | SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC50 of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC50 of 0.5 nM. | |||||||||||||||||||||
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References
Keywords
