SPA107
SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC50 of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC50 of 0.5 nM.
For research use only. We do not sell to patients.
- CAS No.: 179939-69-6
- Formula: C31H48N4O4
- Molecular Weight:540.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.5 nM
Compound: 11, SPA107
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Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay
Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay
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[PMID: 12608848] |
| MCF7 | IC50 |
0.5 nM
Compound: 11, SPA107
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Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay
Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay
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[PMID: 12608848] |
Chemical Information
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CAS No. 179939-69-6
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Molecular Weight 540.74
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Formula C31H48N4O4
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SMILES
COC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
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Synonyms
Hemiasterlin methyl ester
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SPA107 Related Classifications
HY-164923 Related Classifications
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