1809149-40-3
Chemical Structure
Hainantoxin-III
- CAS. Nr.: 1809149-40-3
- Formula:C154H228N44O45S6
- Molecular Weight:3608.12
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(N)=O)NC([C@H]2N(CCC2)C([C@H]3NC([C@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC4=CC=C(C=C4)O)=O)=O)=O)NC5=O)NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC(CNC([C@H]6N(CCC6)C([C@H]([C@H](O)C)NC([C@H](CSSC7)NC([C@H](CO)NC([C@H](CC(O)=O)NC(CNC([C@@H](NC(CNC([C@H](CCCCN)NC([C@H](CSSC3)NC(CN)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](C)C(N[C@@H]7C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC9=CN=CN9)C(N[C@@H](CCCCN)C(N[C@H]5CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively[1].
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Hainantoxin-III | Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively. | |||||||||||||||||||||
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Keywords
