18174-58-8
Chemical Structure
Pipoxolan hydrochloride
- CAS No.: 18174-58-8
- Formula:C22H26ClNO3
- Molecular Weight:387.90
IUPAC Name: 5,5-diphenyl-2-(2-(piperidin-1-yl)ethyl)-1,3-dioxolan-4-one hydrochloride
InChIKey: JXNQXJVDHXGEPU-UHFFFAOYSA-N
SMILES: O=C1OC(CCN2CCCCC2)OC1(C3=CC=CC=C3)C4=CC=CC=C4.Cl
Biological Activity: Pipoxolan hydrochloride is an anti-spasmotic agent. Pipoxolan hydrochloride induces Apoptosis, increases intracellular ROS. Pipoxolan hydrochloride down-regulates phosphorylation JNK and p38, and then, MMP-2 and -9. Pipoxolan hydrochloride relieves smooth muscle spasms in the digestive, urinary, and gynecological systems. Pipoxolan hydrochloride also exhibits anticancer activity against leukemia, oral squamous cell carcinoma, and lung adenocarcinoma[1][2][3][4].
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Pipoxolan hydrochloride | Pipoxolan hydrochloride is an anti-spasmotic agent. Pipoxolan hydrochloride induces Apoptosis, increases intracellular ROS. Pipoxolan hydrochloride down-regulates phosphorylation JNK and p38, and then, MMP-2 and -9. Pipoxolan hydrochloride relieves smooth muscle spasms in the digestive, urinary, and gynecological systems. Pipoxolan hydrochloride also exhibits anticancer activity against leukemia, oral squamous cell carcinoma, and lung adenocarcinoma. | |||||||||||||||||||||
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- [1]. Sheu MJ, et al. Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase. Clin Exp Pharmacol Physiol. 2010 May;37(5-6):605-12. [Content Brief]
- [2]. Chou PY, et al. Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species-mediated Apoptosis. Anticancer Res. 2017 Nov;37(11):6391-6400. [Content Brief]
- [3]. Lee MM, et al. Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2. Chem Biol Interact. 2015 Jul 5;236:19-30. [Content Brief]
- [4]. Chen Y, et al. Novel anti-leukemia activities of pipoxolan operate via the mitochondria-related pathway in human leukemia U937 cells and attenuate U937 cell growth in an animal model. Mol Med Rep. 2010 Sep-Oct;3(5):851-6. [Content Brief]
Keywords
