1835705-48-0
1835705-48-0
Chemical Structure
DAS-6-2-2-CRBN
- CAS No.: 1835705-48-0
- Formula:C43H49ClN10O8S
- Molecular Weight:901.43
InChIKey: DFJPUNQJXZZGBH-UHFFFAOYSA-N
SMILES: CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(CCCCCCOCCOCC(NC5=CC=CC6=C5C(N(C7CCC(NC7=O)=O)C6=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Biological Activity: DAS-6-2-2-CRBN is a Dasatinib (HY-10181)-based cereblon-recruiting proteolysis-targeting chimera (PROTAC). DAS-6-2-2-CRBN degrades c-ABL, BCR-ABL, p-STAT5, and p-CrkL. DAS-6-2-2-CRBN can be used in research on chronic myeloid leukemia (CML)[1].
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DAS-6-2-2-CRBN | DAS-6-2-2-CRBN is a Dasatinib (HY-10181)-based cereblon-recruiting proteolysis-targeting chimera (PROTAC). DAS-6-2-2-CRBN degrades c-ABL, BCR-ABL, p-STAT5, and p-CrkL. DAS-6-2-2-CRBN can be used in research on chronic myeloid leukemia (CML). | |||||||||||||||||||||
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