DAS-6-2-2-CRBN
DAS-6-2-2-CRBN is a Dasatinib (HY-10181)-based cereblon-recruiting proteolysis-targeting chimera (PROTAC). DAS-6-2-2-CRBN degrades c-ABL, BCR-ABL, p-STAT5, and p-CrkL. DAS-6-2-2-CRBN can be used in research on chronic myeloid leukemia (CML).
(Pink: Bcr-Abl ligand (HY-15676); Blue: Cereblon ligand (HY-10984); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 1835705-48-0
- Formula: C43H49ClN10O8S
- Molecular Weight:901.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
Bcr-Abl |
c-ABL |
p-STAT5 |
p-CrkL |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells
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Concentration:25 nM; 100 nM; 250 nM; 1 μM; 2.5 μM; 10μM
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Incubation Time:24 h
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Result:The degradation of c-ABL, BCR-ABL, p-STAT5, and p-CrkL was observed.
Chemical Information
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CAS No. 1835705-48-0
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Molecular Weight 901.43
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Formula C43H49ClN10O8S
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SMILES
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(CCCCCCOCCOCC(NC5=CC=CC6=C5C(N(C7CCC(NC7=O)=O)C6=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DAS-6-2-2-CRBN Related Classifications
HY-191063 Related Classifications
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