1835734-92-3
1835734-92-3
Chemical Structure
AY77
- CAS No.: 1835734-92-3
- Formula:C21H32N4O4
- Molecular Weight:404.50
IUPAC Name: N-((S)-1-(((S)-2-amino-1-cyclohexyl-2-oxoethyl)amino)-3-cyclohexyl-1-oxopropan-2-yl)isoxazole-5-carboxamide
InChIKey: CAYJNBJPGBBDAS-WMZOPIPTSA-N
SMILES: O=C(N)[C@H](C1CCCCC1)NC([C@H](CC2CCCCC2)NC(C3=CC=NO3)=O)=O
Biological Activity: AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].
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AY77 | AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release. | |||||||||||||||||||||
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References
Keywords
