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Cat. No.: HY-138951

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AY77

Name: AY77
Brand: MedChemExpress
SKU: HY-138951
Price: 792.00 USD
Availability: InStock
Rating: 5 (1 reviews)

AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC₅₀ of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca²⁺ release.

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CAS No.: 1835734-92-3
Formule: C₂₁H₃₂N₄O₄
Masse moléculaire:404.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

AY77 Chemical Structure

CAS No.: 1835734-92-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
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Activité biologique

Description

IC₅₀ & Target

PAR2

Voir tous les produits spécifiques à Isoform Protease Activated Receptor (PAR) :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	2 μM Compound: 2; AY77	Agonist activity at PK1-tagged PAR2 (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin recruitment incubated for 90 mins by Pathhunter chemiluminescent assay Agonist activity at PK1-tagged PAR2 (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin recruitment incubated for 90 mins by Pathhunter chemiluminescent assay	[PMID: 32551018]
HEK-293T	EC₅₀	0.17 μM Compound: 2; AY77	Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Galphaq-stimulated IP1 formation incubated for 2 hrs by FRET assay Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Galphaq-stimulated IP1 formation incubated for 2 hrs by FRET assay	[PMID: 32551018]

Chemical Information

CAS No. 1835734-92-3
Masse moléculaire 404.50
Formule C₂₁H₃₂N₄O₄
Sequence

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
Sequence Shortening

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. [Content Brief]

[2]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
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AY77

Vorapaxar

Vorapaxar (Standard)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Atopaxar

Vorapaxar sulfate

ENMD-1068 hydrochloride

I-287

Vorapaxar sulfate (Standard)

Atopaxar hydrobromide

Voir tous les produits spécifiques à Isoform Protease Activated Receptor (PAR)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

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Bioz

AY77

Vorapaxar

Vorapaxar (Standard)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Atopaxar

Vorapaxar sulfate

ENMD-1068 hydrochloride

I-287

Vorapaxar sulfate (Standard)

Atopaxar hydrobromide

Voir tous les produits spécifiques à Isoform Protease Activated Receptor (PAR)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AY77 Related Classifications

HY-138951 Related Classifications

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