184023-52-7
184023-52-7
Chemical Structure
FUB 349
- CAS No.: 184023-52-7
- Formula:C13H16N2
- Molecular Weight:200.28
IUPAC Name: 5-(4-phenylbutyl)-1H-imidazole
InChIKey: BQTXNCXSCSNHGA-UHFFFAOYSA-N
SMILES: C1(CCCCC2=CC=CC=C2)=CN=CN1
Biological Activity: FUB 349 (Compound 8) is a selective Aromatase inhibitor with an IC50 of 12 μM. FUB 349 is also a H3 receptor antagonist with Kis of 12 and 2.1 nM for rH3R and hH3R, respectively. FUB 349 can be used for neurological diseases such as cognitive impairment research[1][2].
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FUB 349 | FUB 349 (Compound 8) is a selective Aromatase inhibitor with an IC50 of 12 μM. FUB 349 is also a H3 receptor antagonist with Kis of 12 and 2.1 nM for rH3R and hH3R, respectively. FUB 349 can be used for neurological diseases such as cognitive impairment research. | |||||||||||||||||||||
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References
- [1]. Karjalainen A, et al. Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons. Eur J Pharm Sci. 2000 Aug;11(2):109-31. [Content Brief]
- [2]. Ligneau X, et al. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50. [Content Brief]
Keywords
