1883545-56-9
1883545-56-9
Chemical Structure
Miglustat-d9
Synonym(s): N-Butyldeoxynojirimycin-d9; NB-DNJ-d9; OGT 918-d9
- CAS No.: 1883545-56-9
- Formula:C10H12D9NO4
- Molecular Weight:228.33
IUPAC Name: (2R,3R,4R,5S)-1-(butyl-d9)-2-(hydroxymethyl)piperidine-3,4,5-triol
InChIKey: UQRORFVVSGFNRO-VYNVFXNFSA-N
SMILES: [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1[C@@H]([C@H]([C@@H]([C@H](C1)O)O)O)CO
Biological Activity: Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].
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Miglustat-d9 | Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). | |||||||||||||||||||||
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Miglustat (Standard) | 99.86% | Miglustat (Standard) is the analytical standard of Miglustat. This product is intended for research and analytical applications. Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease. | ||||||||||||||||||||
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Miglustat | 99.99% | Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-106392RLucerastat (Standard) -
Similarity Score 1.00
HY-162496L-NBDNJ -
Similarity Score 0.89
HY-W706371N-Ethyldeoxynojirimycin hydrochloride -
Similarity Score 0.87
HY-W585938rel-(3R,4S,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride -
Similarity Score 0.84
HY-U00090N-Methylmoranoline -
Similarity Score 0.77
HY-17666(-)-Adenophorine -
Similarity Score 0.77
HY-148601-Deoxynojirimycin -
Similarity Score 0.77
HY-14929Migalastat -
Similarity Score 0.77
HY-1724471,5-Dideoxy-1,5-imino-D-mannitol -
Explore the MedChemAI to find more analogs
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7. [Content Brief]
