192053-05-7
Chemical Structure
MRS1334
- CAS No.: 192053-05-7
- Formula:C31H26N2O6
- Molecular Weight:522.55
IUPAC Name: 3-ethyl 5-(4-nitrobenzyl) 2-methyl-6-phenyl-4-(phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: QFLOJAMZLQXHFS-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC(C2=CC=CC=C2)=C(C(OCC3=CC=C([N+]([O-])=O)C=C3)=O)C1C#CC4=CC=CC=C4)OCC
Biological Activity: MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment[1][2]. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MRS1334 | 98.93% | MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. P G Baraldi, et al. New potent and selective human adenosine A(3) receptor antagonists. Trends Pharmacol Sci. 2000 Dec;21(12):456-9. [Content Brief]
- [2]. Aya Galal, et al. Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol. 2016 Feb;77(2):309-22. [Content Brief]
