19316-85-9
Chemical Structure
5'-Azido-5'-deoxythymidine
- CAS No.: 19316-85-9
- Formula:C10H13N5O4
- Molecular Weight:267.24
IUPAC Name: 1-((2R,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: GKEHVJFBPNPCKI-XLPZGREQSA-N
SMILES: O=C(C(C)=CN1[C@H]2C[C@H](O)[C@@H](CN=[N+]=[N-])O2)NC1=O
Biological Activity: 5'-Azido-5'-deoxythymidine (Compound 7), a nucleoside analogue, is a reverse transcriptase inhibitor. 5'-Azido-5'-deoxythymidine mimics nucleosides and is incorporated into the viral DNA chain to terminate chain elongation, inhibiting viral replication. 5'-Azido-5'-deoxythymidine is promising for research of retroviral infection diseases such as AIDS[1][2].
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5'-Azido-5'-deoxythymidine | 99.06% | 5'-Azido-5'-deoxythymidine (Compound 7), a nucleoside analogue, is a reverse transcriptase inhibitor. 5'-Azido-5'-deoxythymidine mimics nucleosides and is incorporated into the viral DNA chain to terminate chain elongation, inhibiting viral replication. 5'-Azido-5'-deoxythymidine is promising for research of retroviral infection diseases such as AIDS. | ||||||||||||||||||||
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References
- [1]. Neenan JP, Rohde W. Inhibition of thymidine kinase from Walker 256 carcinoma by thymidine analogs. J Med Chem. 1973 May;16(5):580-1. [Content Brief]
- [2]. Baraniak D. Synthesis of nucleoside-cinchona alkaloid conjugates via" click" chemistry[D]. Zakład Chemii Medycznej [nowa struktura organizacyjna], 2012.
