194608-76-9
194608-76-9
Chemical Structure
L-165461
- CAS No.: 194608-76-9
- Formula:C23H26ClNO4S
- Molecular Weight:447.97
IUPAC Name: 2-(3-chloro-4-((3-((3-ethyl-7-propylbenzo[d]isoxazol-6-yl)oxy)propyl)thio)phenyl)acetic acid
InChIKey: LBEYMGDIPDOUKK-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C(C(Cl)=C1)SCCCOC2=C(CCC)C(ON=C3CC)=C3C=C2)O
Biological Activity: L-165461 is a PPARδ and PPARγ agonist with Ki values of 3 nM and 15 nM, respectively. L-165461 can be used for research on diabetes[1][2][3].
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L-165461 | L-165461 is a PPARδ and PPARγ agonist with Ki values of 3 nM and 15 nM, respectively. L-165461 can be used for research on diabetes. | |||||||||||||||||||||
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References
- [1]. Berger J, et al. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. The Journal of biological chemistry. 1999 Mar 05;274(10):6718-25. [Content Brief]
- [2]. Thieringer R, et al. Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro or in vivo[J]. The Journal of Immunology, 2000, 164(2): 1046-1054.
- [3]. Epple R, et al. Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. Journal of medicinal chemistry. 2010 Jan 14;53(1):77-105.
