198710-92-8
Chemical Structure
Kaitocephalin
Synonym(s): PF1191
- CAS 番号: 198710-92-8
- Formula:C18H21Cl2N3O9
- Molecular Weight:494.28
IUPAC Name: (2R,5R)-2-((1S,2R)-2-amino-2-carboxy-1-hydroxyethyl)-5-((S)-2-carboxy-2-(3,5-dichloro-4-hydroxybenzamido)ethyl)pyrrolidine-2-carboxylic acid
InChIKey: AJQRDRIPQOAJCM-BWOKQULHSA-N
SMILES: OC([C@H](N)[C@@H]([C@@]1(N[C@@H](C[C@@H](C(O)=O)NC(C2=CC(Cl)=C(O)C(Cl)=C2)=O)CC1)C(O)=O)O)=O
Biological Activity: Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with Ki values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease[1].
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Kaitocephalin | Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with Ki values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease. | |||||||||||||||||||||
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