1998714-25-2
Chemical Structure
LY3325656
- CAS No.: 1998714-25-2
- Formula:C21H23F3N6O2
- Molecular Weight:448.45
IUPAC Name: N-((2S,4R)-2-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
InChIKey: LEKZBCFOSTUBJZ-CVEARBPZSA-N
SMILES: CC1=C(N(C)C=N1)C=2NC(=NN2)[C@@H]3C[C@H](N(C(=O)C4=CC(C(F)(F)F)=CC=C4)C)CCO3
Biological Activity: LY3325656 is a selective GPR142 agonist. LY3325656 selectively activates GPR142. LY increases glucose-dependent insulin secretion. LY3325656 shows anti-diabetic effects. LY3325656 can be used in the research of type 2 diabetes[1][2].
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LY3325656 | LY3325656 is a selective GPR142 agonist. LY3325656 selectively activates GPR142. LY increases glucose-dependent insulin secretion. LY3325656 shows anti-diabetic effects. LY3325656 can be used in the research of type 2 diabetes. | |||||||||||||||||||||
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- [1]. Liu LZ, et al. Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human. Bioorg Med Chem Lett. 2020 Mar 1;30(5):126857. [Content Brief]
- [2]. Pratt E J, et al. 20-OR: GPR142 agonists increase glucose-dependent insulin secretion and differentially regulate hormone secretion in preclinical and phase 1 studies[J]. Diabetes, 2019, 68(Supplement_1).
Keywords
