2012563-29-8
Chemical Structure
Mcl1-IN-14
- CAS No.: 2012563-29-8
- Formula:C35H32BN3O7
- Molecular Weight:617.46
IUPAC Name: 7-(3-((4-borono-3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
InChIKey: RMIRRIJMEIKMFL-UHFFFAOYSA-N
SMILES: O=C(O)C(NC1=C2C=CC=C1C3=C(N(N=C3COC4=CC=C(C(C=O)=C4)B(O)O)C)C)=C2CCCOC5=C6C=CC=CC6=CC=C5
Biological Activity: Mcl1-IN-14 (compound 5) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. Mcl1-IN-14 covalently targets the non-catalytic lysine side chain of Mcl-1 and has higher potency than non-covalent counterparts, which can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.
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Mcl1-IN-14 | Mcl1-IN-14 (compound 5) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. Mcl1-IN-14 covalently targets the non-catalytic lysine side chain of Mcl-1 and has higher potency than non-covalent counterparts, which can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena. | |||||||||||||||||||||
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Keywords
