2043660-80-4
Chemical Structure
CPUL1
- CAS 番号: 2043660-80-4
- Formula:C22H13Cl2N5O
- Molecular Weight:434.28
IUPAC Name: 3,5-diamino-1-(3,4-dichlorophenyl)-1H-pyrano[3,2-a]phenazine-2-carbonitrile
InChIKey: HTMNMHIFUPOACL-UHFFFAOYSA-N
SMILES: N#CC1=C(OC2=C(C1C3=CC(Cl)=C(Cl)C=C3)C4=NC5=CC=CC=C5N=C4C=C2N)N
Biological Activity: CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1].
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CPUL1 | CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective. | |||||||||||||||||||||
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Keywords
