2055101-66-9
Chemical Structure
SR12460
- CAS 番号: 2055101-66-9
- Formula:C15H14ClF2N3O
- Molecular Weight:325.74
IUPAC Name: N-(5-chloropyridin-2-yl)-2-((3,5-difluorophenethyl)amino)acetamide
InChIKey: MQWIKNJATTZAPQ-UHFFFAOYSA-N
SMILES: O=C(CNCCC1=CC(F)=CC(F)=C1)NC2=NC=C(C=C2)Cl
Biological Activity: SR12460 is a NEMO-binding domain mimetic and an inhibitor of the IKKβ-NEMO complex with an IC50 of 11.34 μM. SR12460 disrupts the IKKβ-NEMO interaction, thereby inhibiting NF-κB activation, including TNF-α- and LPS-induced NF-κB activation. SR12460 inhibits LPS-induced acute lung inflammation in mice and alleviates inflammatory infiltration, necrosis, and muscle degeneration in a mouse model of Duchenne muscular dystrophy. SR12460 is used for research on acute lung inflammation and Duchenne muscular dystrophy[1].
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SR12460 | SR12460 is a NEMO-binding domain mimetic and an inhibitor of the IKKβ-NEMO complex with an IC50 of 11.34 μM. SR12460 disrupts the IKKβ-NEMO interaction, thereby inhibiting NF-κB activation, including TNF-α- and LPS-induced NF-κB activation. SR12460 inhibits LPS-induced acute lung inflammation in mice and alleviates inflammatory infiltration, necrosis, and muscle degeneration in a mouse model of Duchenne muscular dystrophy. SR12460 is used for research on acute lung inflammation and Duchenne muscular dystrophy. | |||||||||||||||||||||
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