20696-60-0
20696-60-0
Chemical Structure
Tryptophyltryptophan
Synonym(s): NSC 524592
- CAS No.: 20696-60-0
- Formula:C22H22N4O3
- Molecular Weight:390.44
InChIKey: NQIHMZLGCZNZBN-PXNSSMCTSA-N
SMILES: N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(O)=O)CC3=CNC4=CC=CC=C34)=O
Biological Activity: Tryptophyltryptophan (NSC 524592) is a peptide bitter taste receptor modulator and peptide crosslinker. Tryptophyltryptophan competitively inhibits hTAS2R14 (IC50 of 210 μM), and also inhibits hTAS2R16 (IC50 = 1.3 mM), hTAS2R43 (IC50 = 320 μM) and hTAS2R46 (IC50 = 55 μM), while slightly activating hTAS2R39[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tryptophyltryptophan | 99.49% | Tryptophyltryptophan (NSC 524592) is a peptide bitter taste receptor modulator and peptide crosslinker. Tryptophyltryptophan competitively inhibits hTAS2R14 (IC50 of 210 μM), and also inhibits hTAS2R16 (IC50 = 1.3 mM), hTAS2R43 (IC50 = 320 μM) and hTAS2R46 (IC50 = 55 μM), while slightly activating hTAS2R39. | ||||||||||||||||||||
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References
- [1]. Makwana KM, et al. Trp-Trp Cross-Linking: A Structure-Reactivity Relationship in the Formation and Design of Hyperstable Peptide β-Hairpin and α-Helix Scaffolds. Org Lett. 2015 May 15;17(10):2498-501.
- [2]. Ojiro I, et al. Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46. Bioscience, biotechnology, and biochemistry. 2021 May 25;85(6):1526-1529. [Content Brief]
