Tryptophyltryptophan
Based on 1 Customer Validation
Tryptophyltryptophan (NSC 524592) is a peptide bitter taste receptor modulator and peptide crosslinker. Tryptophyltryptophan competitively inhibits hTAS2R14 (IC50 of 210 μM), and also inhibits hTAS2R16 (IC50 = 1.3 mM), hTAS2R43 (IC50 = 320 μM) and hTAS2R46 (IC50 = 55 μM), while slightly activating hTAS2R39.
For research use only. We do not sell to patients.
- Purity : 99.49%
- CAS No.: 20696-60-0
- Formula: C22H22N4O3
- Molecular Weight:390.44
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
210 μM
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Inhibition of tangeretin-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
Inhibition of tangeretin-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
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33844825 |
| HEK-293T | IC50 |
230 μM
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Inhibition of aristolochic acid-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
Inhibition of aristolochic acid-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
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33844825 |
| HEK-293T | IC50 |
320 μM
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Inhibition of flufenamic acid-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
Inhibition of flufenamic acid-induced hTAS2R14-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R14 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
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33844825 |
| HEK-293T | IC50 |
1.3 mM
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Inhibition of hTAS2R16-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R16 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
Inhibition of hTAS2R16-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R16 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
|
33844825 |
| HEK-293T | IC50 |
55 μM
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Inhibition of hTAS2R46-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R46 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
Inhibition of hTAS2R46-mediated intracellular Ca2+ mobilization in HEK293T cells transiently co-transfected with hTAS2R46 and hGα16gust44 and loaded with Fluo-8 AM measured by fluorescence.
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33844825 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 20696-60-0
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Appearance Solid
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Molecular Weight 390.44
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Formula C22H22N4O3
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Color White to off-white
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Synonyms
NSC 524592
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Sequence
Trp-Trp
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Sequence Shortening
WW
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (256.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (278 KB)
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SDS (585 KB)
- English - EN (585 KB)
- Français - FR (585 KB)
- Deutsch - DE (585 KB)
- Norwegian - NO (585 KB)
- Español - ES (585 KB)
- Swedish - SV (585 KB)
- Italian - IT (585 KB)
- Korean - KR (585 KB)
- Portuguese - PT (585 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5612 mL | 12.8061 mL | 25.6121 mL | 64.0303 mL |
| 5 mM | 0.5122 mL | 2.5612 mL | 5.1224 mL | 12.8061 mL | |
| 10 mM | 0.2561 mL | 1.2806 mL | 2.5612 mL | 6.4030 mL | |
| 15 mM | 0.1707 mL | 0.8537 mL | 1.7075 mL | 4.2687 mL | |
| 20 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2015 mL | |
| 25 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 30 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1343 mL | |
| 40 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL | |
| 60 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL | |
| 80 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8004 mL | |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2561 mL | 0.6403 mL |
Tryptophyltryptophan Related Classifications
HY-P4647 Related Classifications
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