Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

  • Biosci Biotechnol Biochem. 2021 May 25;85(6):1526-1529. doi: 10.1093/bbb/zbab061.
Ichie Ojiro  1 ,  Hiromi Nishio  1 ,  Toyomi Yamazaki-Ito  1  2 ,  Shogo Nakano  1  2 ,  Sohei Ito  1  2 ,  Yoshikazu Toyohara  3 ,  Tadahiro Hiramoto  3 ,  Yuko Terada  1  2 ,  Keisuke Ito  1  2
Affiliations
  • 1. Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • 2. School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • 3. Corporate Research and Development Division, Takasago International Corporation, Hiratsuka, Kanagawa, Japan.
PMID: 33844825 DOI: 10.1093/bbb/zbab061
Abstract

Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.

Keywords
bitter taste receptor; bitterness masking; dipeptide.
Products