2095172-11-3
2095172-11-3
Chemical Structure
RET-IN-2
- CAS No.: 2095172-11-3
- Formula:C13H16N6O2
- Molecular Weight:288.31
IUPAC Name: 1-(3-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)isoxazol-5-yl)ethan-1-ol
InChIKey: ITFXSJIKNXDVJJ-UHFFFAOYSA-N
SMILES: OC(C=1ON=C(C1)C2=NN(C3=NC=NC(N)=C23)C(C)C)C
Biological Activity: RET-IN-2 is a selective RET inhibitor with an IC50 of 61.2 nM. RET-IN-2 inhibits the phosphorylation of RET and its downstream STAT3 and AKT proteins in BaF3/CCDC6-RET cells. RET-IN-2 inhibits the proliferation of RET fusion-positive cells. RET-IN-2 can be used for cancer-related research[1].
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RET-IN-2 | RET-IN-2 is a selective RET inhibitor with an IC50 of 61.2 nM. RET-IN-2 inhibits the phosphorylation of RET and its downstream STAT3 and AKT proteins in BaF3/CCDC6-RET cells. RET-IN-2 inhibits the proliferation of RET fusion-positive cells. RET-IN-2 can be used for cancer-related research. | |||||||||||||||||||||
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